Validated Bioanalytical Assays
We offer a wide range of clinical and preclinical non-proprietary assays validated to current regulatory guidelines. If your compound is not listed, please contact us. We have vast experience developing and validating small- and large-molecule assays and can usually support your bioanalytical project at short notice.
Validated Bioanalytical Assays
Our range of state-of-the-art instrumentation and technologies includes:
- Waters Xevo™ TQ-XS and TQ-S LC-MS/MS systems
- AB SCIEX API 4000™, 5000™ and TQ 6500+™ LC-MS/MS systems
- Waters Acquity I-Class UPLC™ and Shimadzu Nexera UHPLC systems
- Hamilton MicroLab Star robotics systems
- Spark-Holland Symbiosis™ Pharma systems
- Immunoassay
- MSD systems
- Watson LIMS and Labnotes ELN
| Compound | LLOQ | ULOQ | Species & Matrix | Type |
|---|---|---|---|---|
| 1-Hydroxymidazolam | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| 4'-Hydroxyflurbiprofen | 0.25 µg/mL | 25 µg/mL | Human Urine | LC-MS/MS |
| 4-Hydroxytolbutamide | 10 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| 5-Aminosalicylic Acid (ASA) | 5.0 µg/mL | 1,000 µg/mL | Human Urine | LC-MS/MS |
| 5-Aminosalicylic Acid (ASA) | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| 5-Hydroxyomeprazole | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| 6ß-Hydroxycortisol | 200 ng/mL | 35,000 ng/mL | Human Urine | LC-MS/MS |
| 7-Hydroxymethotrexate | 5.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| 7-Hydroxymethotrexate | 20 ng/mL | 15,000 ng/mL | Human Urine | LC-MS/MS |
| 9-Hydroxyrisperidone | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| 17-Hydroxyexemestane | 50 pg/mL | 5,000 pg/mL | Human Plasma | LC-MS/MS |
| 24,25-Dihydroxycholecalciferol | 50 pg/mL | 10,000 pg/mL | Human Plasma | LC-MS/MS |
| Adefovir | 0.5 ng/mL | 500 ng/mL | Human Plasma | LC-MS/MS |
| Amoxicillin | 100 ng/mL | 20,000 ng/mL | Human Plasma | LC-MS/MS |
| Atomoxetine | 5 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Budesonide | 5.0 pg/mL | 1,000 pg/mL | Human Serum | LC-MS/MS |
| Buprenorphine | 1.0 pg/mL | 1,000 pg/mL | Human Plasma | LC-MS/MS |
| Caffeine | 20 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Calcifediol | 1.0 ng/mL | 200 ng/mL | Human Plasma | LC-MS/MS |
| Calcitriol | 10 pg/mL | 2,000 pg/mL | Human Plasma | LC-MS/MS |
| Candesartan | 0.5 ng/mL | 250 ng/mL | Human Plasma | LC-MS/MS |
| Ciprofloxacin | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Clopidogrel carboxylic acid | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Cortisol | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Cortisol | 40 ng/mL | 7,000 ng/mL | Human Urine | LC-MS/MS |
| C-Reactive Protein (CRP) | 1.0 ng/mL | 100 ng/mL | Human Plasma | ELISA |
| Cyclosporin | 20 ng/mL | 4,000 ng/mL | Human Whole Blood | LC-MS/MS |
| Dextromethorphan | 10 ng/mL | 2,000 ng/mL | Human Urine | LC-MS/MS |
| Dextrorphan | 100 ng/mL | 20,000 ng/mL | Human Urine | LC-MS/MS |
| Digoxin | 0.1 ng/mL | 5.0 ng/mL | Human Plasma | LC-MS/MS |
| Dihydrotestosterone | 100 pg/mL | 5,000 ng/mL | Human Serum | LC-MS/MS |
| Diltiazem | 1.0 ng/mL | 250 ng/mL | Human Plasma | LC-MS/MS |
| Docetaxel | 0.5 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Exemestane | 0.1 ng/mL | 25 ng/mL | Human Plasma | LC-MS/MS |
| Flurbiprofen | 0.1 µg/mL | 20 µg/mL | Human Plasma | LC-MS/MS |
| Flurbiprofen | 0.25 µg/mL | 25 µg/mL | Human Urine | LC-MS/MS |
| Fluticasone Propionate | 3.0 pg/mL | 200 pg/mL | Human Plasma | LC-MS/MS |
| Fluticasone Propionate and Salmeterol | 0.5 pg/mL | 200 pg/mL | Human Plasma (200 µL) | LC-MS/MS |
| Glibenclamide | 2.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Glipizide | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Hydroxyitraconazole | 1.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Hydroxymetronidazole | 100 ng/mL | 10,000 ng/mL | Human Plasma | LC-MS/MS |
| Itraconazole | 1.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Ketoconazole | 10 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Lamivudine | 2.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Lorazepam | 1.0 ng/mL | 150 ng/mL | Human Plasma | LC-MS/MS |
| Metformin | 10 ng/mL | 10,000 ng/mL | Human Plasma | LC-MS/MS |
| Methotrexate | 5.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Methotrexate | 50 ng/mL | 1,000 ng/mL | Human Urine | LC-MS/MS |
| Metronidazole | 500 ng/mL | 30,000 ng/mL | Human Plasma | LC-MS/MS |
| Midazolam | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Moxifloxacin | 50 ng/mL | 7,500 ng/mL | Human Plasma | LC-MS/MS |
| N-Acetyl-5-Aminosalicylic Acid (NASA) | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| N-Acetyl-5-Aminosalicylic Acid (NASA) | 5.0 µg/mL | 5,000 µg/mL | Human Urine | LC-MS/MS |
| Norbuprenorphine | 5.0 pg/mL | 1,000 pg/mL | Human Plasma | LC-MS/MS |
| O-Desmethyl Venlafaxine | 1.0 ng/mL | 400 ng/mL | Human Plasma | LC-MS/MS |
| Omeprazole | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Omeprazole Sulphone | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Paraxanthine | 20 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Pioglitazone | 25 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Pioglitazone MIV | 25 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Pravastatin | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Prednisolone | 0.5 ng/mL | 500 ng/mL | Human Plasma | LC-MS/MS |
| Prednisolone | 20 ng/mL | 20,000 ng/mL | Human Plasma | LC-MS/MS |
| Risperidone | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Salbutamol | 50 pg/mL | 10,000 pg/mL | Human Plasma | LC-MS/MS |
| Salbutamol | 3.0 ng/mL | 1,000 ng/mL | Human Urine | LC-MS/MS |
| Salmeterol | 5.0 pg/mL | 1,000 pg/mL | Human Plasma | LC-MS/MS |
| Salmeterol | 1.0 pg/mL | 200 pg/mL | Human Plasma | LC-MS/MS |
| Salmeterol and Fluticasone Propionate | 0.5 pg/mL | 200 pg/mL | Human Plasma (200 µL) | LC-MS/MS |
| Simvastatin | 0.05 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Simvastatin Acid | 0.05 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Sitagliptin | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Sulfamethoxazole | 1.0 µg/mL | 100 µg/mL | Human Plasma | LC-MS/MS |
| Testosterone | 250 pg/mL | 50,000 pg/mL | Human Serum | LC-MS/MS |
| Testosterone | 50 pg/mL | 25,000 pg/mL | Human Serum | LC-MS/MS |
| Tolbutamide | 10 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Venlafaxine | 1.0 ng/mL | 400 ng/mL | Human Plasma | LC-MS/MS |
| Warfarin (R & S) | 20 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |