Validated Methods
We offer a wide range of clinical and preclinical non-proprietary assays, validated in accordance with current regulatory guidelines. If your compound is not listed, please contact us. Our team has extensive experience in developing and validating assays for both small and large molecules, and we are typically able to support your bioanalytical project at short notice.
Validated Bioanalytical Assays
Our range of advanced instrumentation and technologies includes:
- Waters Xevo™ TQ-XS and TQ-S LC-MS/MS systems
- AB SCIEX API 4000™, 5000™ and TQ 6500+™ LC-MS/MS systems
- Waters Acquity I-Class UPLC™ and Shimadzu Nexera UHPLC systems
- Hamilton MicroLab Star robotics systems
- Spark-Holland Symbiosis™ Pharma systems
- Immunoassay
- MSD systems
- Watson LIMS and Labnotes ELN
| Compound | LLOQ | ULOQ | Species & Matrix | Type |
|---|---|---|---|---|
| 1-Hydroxymidazolam | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| 4'-Hydroxyflurbiprofen | 0.25 µg/mL | 25 µg/mL | Human Urine | LC-MS/MS |
| 4-Hydroxytolbutamide | 10 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| 5-Aminosalicylic Acid (ASA) | 5.0 µg/mL | 1,000 µg/mL | Human Urine | LC-MS/MS |
| 5-Aminosalicylic Acid (ASA) | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| 5-Hydroxyomeprazole | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| 6ß-Hydroxycortisol | 200 ng/mL | 35,000 ng/mL | Human Urine | LC-MS/MS |
| 7-Hydroxymethotrexate | 5.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| 7-Hydroxymethotrexate | 20 ng/mL | 15,000 ng/mL | Human Urine | LC-MS/MS |
| 9-Hydroxyrisperidone | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| 17-Hydroxyexemestane | 50 pg/mL | 5,000 pg/mL | Human Plasma | LC-MS/MS |
| 24,25-Dihydroxycholecalciferol | 50 pg/mL | 10,000 pg/mL | Human Plasma | LC-MS/MS |
| Adefovir | 0.5 ng/mL | 500 ng/mL | Human Plasma | LC-MS/MS |
| Amoxicillin | 100 ng/mL | 20,000 ng/mL | Human Plasma | LC-MS/MS |
| Atomoxetine | 5 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Budesonide | 5.0 pg/mL | 1,000 pg/mL | Human Serum | LC-MS/MS |
| Buprenorphine | 1.0 pg/mL | 1,000 pg/mL | Human Plasma | LC-MS/MS |
| Caffeine | 20 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Calcifediol | 1.0 ng/mL | 200 ng/mL | Human Plasma | LC-MS/MS |
| Calcitriol | 10 pg/mL | 2,000 pg/mL | Human Plasma | LC-MS/MS |
| Candesartan | 0.5 ng/mL | 250 ng/mL | Human Plasma | LC-MS/MS |
| Ciprofloxacin | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Clopidogrel carboxylic acid | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Cortisol | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Cortisol | 40 ng/mL | 7,000 ng/mL | Human Urine | LC-MS/MS |
| C-Reactive Protein (CRP) | 1.0 ng/mL | 100 ng/mL | Human Plasma | ELISA |
| Cyclosporin | 20 ng/mL | 4,000 ng/mL | Human Whole Blood | LC-MS/MS |
| Dextromethorphan | 10 ng/mL | 2,000 ng/mL | Human Urine | LC-MS/MS |
| Dextrorphan | 100 ng/mL | 20,000 ng/mL | Human Urine | LC-MS/MS |
| Digoxin | 0.1 ng/mL | 5.0 ng/mL | Human Plasma | LC-MS/MS |
| Dihydrotestosterone | 100 pg/mL | 5,000 ng/mL | Human Serum | LC-MS/MS |
| Diltiazem | 1.0 ng/mL | 250 ng/mL | Human Plasma | LC-MS/MS |
| Docetaxel | 0.5 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Exemestane | 0.1 ng/mL | 25 ng/mL | Human Plasma | LC-MS/MS |
| Flurbiprofen | 0.1 µg/mL | 20 µg/mL | Human Plasma | LC-MS/MS |
| Flurbiprofen | 0.25 µg/mL | 25 µg/mL | Human Urine | LC-MS/MS |
| Fluticasone Propionate | 3.0 pg/mL | 200 pg/mL | Human Plasma | LC-MS/MS |
| Fluticasone Propionate and Salmeterol | 0.5 pg/mL | 200 pg/mL | Human Plasma (200 µL) | LC-MS/MS |
| Glibenclamide | 2.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Glipizide | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Hydroxyitraconazole | 1.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Hydroxymetronidazole | 100 ng/mL | 10,000 ng/mL | Human Plasma | LC-MS/MS |
| Itraconazole | 1.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Ketoconazole | 10 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Lamivudine | 2.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Lorazepam | 1.0 ng/mL | 150 ng/mL | Human Plasma | LC-MS/MS |
| Metformin | 10 ng/mL | 10,000 ng/mL | Human Plasma | LC-MS/MS |
| Methotrexate | 5.0 ng/mL | 1,000 ng/mL | Human Plasma | LC-MS/MS |
| Methotrexate | 50 ng/mL | 1,000 ng/mL | Human Urine | LC-MS/MS |
| Metronidazole | 500 ng/mL | 30,000 ng/mL | Human Plasma | LC-MS/MS |
| Midazolam | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Moxifloxacin | 50 ng/mL | 7,500 ng/mL | Human Plasma | LC-MS/MS |
| N-Acetyl-5-Aminosalicylic Acid (NASA) | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| N-Acetyl-5-Aminosalicylic Acid (NASA) | 5.0 µg/mL | 5,000 µg/mL | Human Urine | LC-MS/MS |
| Norbuprenorphine | 5.0 pg/mL | 1,000 pg/mL | Human Plasma | LC-MS/MS |
| O-Desmethyl Venlafaxine | 1.0 ng/mL | 400 ng/mL | Human Plasma | LC-MS/MS |
| Omeprazole | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Omeprazole Sulphone | 5.0 ng/mL | 2,000 ng/mL | Human Plasma | LC-MS/MS |
| Paraxanthine | 20 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Pioglitazone | 25 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Pioglitazone MIV | 25 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Pravastatin | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Prednisolone | 0.5 ng/mL | 500 ng/mL | Human Plasma | LC-MS/MS |
| Prednisolone | 20 ng/mL | 20,000 ng/mL | Human Plasma | LC-MS/MS |
| Risperidone | 0.1 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Salbutamol | 50 pg/mL | 10,000 pg/mL | Human Plasma | LC-MS/MS |
| Salbutamol | 3.0 ng/mL | 1,000 ng/mL | Human Urine | LC-MS/MS |
| Salmeterol | 5.0 pg/mL | 1,000 pg/mL | Human Plasma | LC-MS/MS |
| Salmeterol | 1.0 pg/mL | 200 pg/mL | Human Plasma | LC-MS/MS |
| Salmeterol and Fluticasone Propionate | 0.5 pg/mL | 200 pg/mL | Human Plasma (200 µL) | LC-MS/MS |
| Simvastatin | 0.05 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Simvastatin Acid | 0.05 ng/mL | 100 ng/mL | Human Plasma | LC-MS/MS |
| Sitagliptin | 5.0 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Sulfamethoxazole | 1.0 µg/mL | 100 µg/mL | Human Plasma | LC-MS/MS |
| Testosterone | 250 pg/mL | 50,000 pg/mL | Human Serum | LC-MS/MS |
| Testosterone | 50 pg/mL | 25,000 pg/mL | Human Serum | LC-MS/MS |
| Tolbutamide | 10 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |
| Venlafaxine | 1.0 ng/mL | 400 ng/mL | Human Plasma | LC-MS/MS |
| Warfarin (R & S) | 20 ng/mL | 5,000 ng/mL | Human Plasma | LC-MS/MS |