In Vitro ADME
We offer a comprehensive range of in vitro ADME assays, from early discovery screens to definitive development studies. Our services combine efficient generic automated screening with assay solutions adapted to your study requirements, validated through robust quality processes.
Tailored In Vitro ADME Assays for Drug Discovery and Development
Key Services:
- Comprehensive in vitro ADME assays from early discovery to development
- Assay design and validation adapted to project-specific requirements
- Metabolic stability and liability assessments across multiple species and matrices
- Binding studies to plasma proteins, tissues, and microsomes (equilibrium dialysis/ultracentrifugation/ultrafiltration)
- Blood:plasma partitioning
- Reaction phenotyping
- Inhibition studies of P450s/UGTs
- Permeability and absorption studies using Caco-2 and MDCK cell lines
- Identification of reactive metabolites and evaluation of physicochemical properties
Comprehensive, customised in vitro assays to evaluate drug metabolism, stability, and absorption properties.
Applications: Our services help understand drug behavior and inform chemical design strategies by identifying metabolic vulnerabilities. We support regulatory submissions through comprehensive data generation and facilitate understanding of absorption, distribution, metabolism, and excretion (ADME) profiles for drug candidates.
Instrumentation: We utilise advanced technologies, including:
- AB SCIEX Triple Quad 6500+ for quantitative analysis
- Orbitrap and Q-Tof High-Resolution Mass Spectrometers
- Hamilton Star Liquid Handling Robot for HT-ADME studies