Biomarker Analysis
We offer a validated portfolio of biomarker assays designed for use in regulated research and development settings
Biomarker Discovery & Validation
The information below details the therapeutic areas where we currently offer validated methods. The range of equipment and techniques available is constantly being reviewed and includes electrochemiluminescence using the Meso Scale Discovery (MSD) system and Gyrolab.
Key Services:
- Fully validated biomarker assays covering >15 therapeutic areas
- Bespoke method development / validation for additional biomarkers on request
- Safety monitoring of biologicals and clinical-study samples
- Continuous platform expansion (e.g. MSD electrochemiluminescence, Gyrolab nanolitre immunoassay)
- End-to-end project management: sample logistics, analysis, data reporting and QA support
Comprehensive biomarker discovery and validation supporting clinical trials under GLP and GCP compliance
Therapeutic Areas:
- Allergy panels
- Obesity, diabetes & growth biomarkers
- Bone-turnover markers
- Cardiac markers
- Endocrine panels – adrenal, thyroid, reproductive, metabolic
- Faecal fat & occult-blood analyses
- Haematology & coagulation markers
- Inflammatory panels
- Hepatic enzymes
- Trace-metal analyses
- Tumour, apoptosis & proliferation markers
- Leucocyte phenotyping
- Safety monitoring of biological therapies
- Additional biomarkers validated on demand
Instrumentation & Analytical Techniques:
Core Platforms
- Meso Scale Discovery (MSD) electrochemiluminescence
- Gyrolab nanolitre immunoassay workstation
Immunoassay Methods
- CLIA – Chemiluminescence Immunoassay
- ECLIA – Electrochemiluminescence Immunoassay
- ELISA / EIA (absorbance)
- ELFA / FEIA (fluorescence)
- FPIA – Fluorescence Polarisation Immunoassay
- EMIT – Enzyme-Multiplied Immunoassay
- Immunoturbidimetry
- RIA – Radioimmunoassay
Mass Spectrometry
- GC-MS
- ICP-MS
- LC-MS / LC-MS/MS
Liquid & Ion Chromatography
- HPLC
- LC (analytical & preparative)
- Equilibrium dialysis
Additional Analytical Capabilities
- Agglutination, complement fixation, immunochromatographic tests
- Atomic-absorption spectrometry, X-ray diffraction
- Nephelometry, turbidimetry, spectrophotometry, fluorometry
- Electrophoresis, titrimetry, enzyme-activity kinetics
- PCR, cell culture, microscopy, cryo-precipitation
- Coagulation, haematology, impedance, ion-selective electrode, freezing-point depression, Stix